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JWH-018, JWH-018-M5 and JWH-073-M5 require significantly less fractional receptor occupancy (FRO) of CB 2 Rs to produce half-maximal inhibition of AC than established cannabinoids The law of mass action predicts that, at equilibrium, the FRO is the proportion of all receptors that are bound by drug at a given concentration ( Tallarida, 1990 ).JWH-018 is available for order JWH-018 can be ordered online and delivered for free anywhere in the United States. JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678[1] is a naphthoylindole-derived analgesic that operates as a complete agonist at both CB1 and CB2 cannabinoid receptors, with slight selectivity for CB2.

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